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TRAP1 antibody

GTX102017
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
TargetTRAP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    TRAP1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.22 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10131
  • Target name
    TRAP1
  • Target description
    TNF receptor associated protein 1
  • Target synonyms
    HSP 75, HSP75, HSP90L, TRAP-1, heat shock protein 75 kDa, mitochondrial, TNFR-associated protein 1, heat shock protein family C member 5, testicular tissue protein Li 209, tumor necrosis factor type 1 receptor-associated protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ12931
  • Protein Name
    Heat shock protein 75 kDa, mitochondrial
  • Scientific Description
    HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and endoplasmic reticulum (HSP90B1; MIM 191175) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Avolio R, Agliarulo I, Criscuolo D, et al. Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins. Genome Res. 2023,33(8):1242-1257. doi: 10.1101/gr.277755.123
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  • Avolio R, Agliarulo I, Criscuolo D, et al. Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins. bioRxiv. 2023,:pii: 2023.01.19.524708. doi: 10.1101/2023.01.19.524708.
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  • Matassa DS, Criscuolo D, Avolio R, et al. Regulation of mitochondrial complex III activity and assembly by TRAP1 in cancer cells. Cancer Cell Int. 2022,22(1):402. doi: 10.1186/s12935-022-02788-4
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  • Chen JH, Wu CH, Jheng JR, et al. The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition. J Biomed Sci. 2022,29(1):46. doi: 10.1186/s12929-022-00828-9
    Read this paper
  • Lee Y, Fong SY, Shon J, et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle. Sci Adv. 2021,7(7). doi: 10.1126/sciadv.abd2645
    Read this paper
  • Lanzillotta C, Zuliani I, Tramutola A, et al. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2021,196:101892. doi: 10.1016/j.pneurobio.2020.101892
    Read this paper
  • Zhao X, Sun K, Lan Z, et al. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017,7:46344. doi: 10.1038/srep46344
    Read this paper
  • Brauers E, Roos A, Kollipara L, et al. The Caveolin-3 G56S sequence variant of unknown significance: Muscle biopsy findings and functional cell biological analysis. Proteomics Clin Appl. 2017,11(1-2). doi: 10.1002/prca.201600007
    Read this paper