TRF1 antibody [4E4]
GTX70304
ApplicationsImmunoFluorescence, ImmunoCytoChemistry
Product group Antibodies
TargetTERF1
Overview
- SupplierGeneTex
- Product NameTRF1 antibody [4E4]
- Delivery Days Customer9
- Application Supplier NoteICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7013
- Target nameTERF1
- Target descriptiontelomeric repeat binding factor 1
- Target synonymsPIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1, telomeric repeat-binding factor 1, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, telomeric protein Pin2/TRF1, telomeric repeat binding factor (NIMA-interacting) 1
- HostMouse
- IsotypeIgG1
- Protein IDP54274
- Protein NameTelomeric repeat-binding factor 1
- Scientific DescriptionThis gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chen L, Zhang C, Ma W, et al. METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability. Nucleic Acids Res. 2022,50(20):11619-11634. doi: 10.1093/nar/gkac1027Read this paper
- Li X, Xie C, et al. cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence. Protein Cell. 2022,13(1):47-64. doi: 10.1007/s13238-021-00879-yRead this paper
- Sandhu R, Sharma M, Wei D, et al. The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment. Proc Natl Acad Sci U S A. 2021,118(30). doi: 10.1073/pnas.2024889118Read this paper
- Wu S, Ge Y, Li X, et al. BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1. PLoS Genet. 2020,16(6):e1008799. doi: 10.1371/journal.pgen.1008799Read this paper
- Sandhu R, Wei D, Sharma M, et al. An N-terminal Flag-tag impairs TPP1 regulation of telomerase function. Biochem Biophys Res Commun. 2019,512(2):230-235. doi: 10.1016/j.bbrc.2019.03.050Read this paper
- Zhang T, Zhang Z, Li F, et al. Looping-out mechanism for resolution of replicative stress at telomeres. EMBO Rep. 2017,18(8):1412-1428. doi: 10.15252/embr.201643866Read this paper
- Nera B, Huang HS, Lai T, et al. Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nat Commun. 2015,6:10132. doi: 10.1038/ncomms10132Read this paper
- Cheng J, Liu W, Zeng X, et al. XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma. Cancer Sci. 2015,106(12):1678-86. doi: 10.1111/cas.12820Read this paper
- Tian XP, Qian D, He LR, et al. The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas. Cancer Lett. 2014,353(1):104-14. doi: 10.1016/j.canlet.2014.07.012Read this paper
- Siddiqa A, Cavazos D, Chavez J, et al. Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase. J Oncol. 2012,2012:806382. doi: 10.1155/2012/806382Read this paper
Datasheet
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