Bio-Connect

TRF1 antibody [4E4]

Research Use Only
GTX70304
GeneTex
ApplicationsImmunoFluorescence, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetTERF1
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Overview

  • Supplier
    GeneTex
  • Product Name
    TRF1 antibody [4E4]
  • Delivery Days Customer
    9
  • Application Supplier Note
    ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    4E4
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7013
  • Target name
    TERF1
  • Target description
    telomeric repeat binding factor 1
  • Target synonyms
    hTRF1-AS; NIMA-interacting protein 2; PIN2; telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat-binding factor 1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1; t-TRF1
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP54274
  • Protein Name
    Telomeric repeat-binding factor 1
  • Scientific Description
    This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability. Chen L et al., 2022 Nov 11, Nucleic Acids Res
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  • cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence. Li X et al., 2022 Jan, Protein Cell
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  • The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment. Sandhu R et al., 2021 Jul 27, Proc Natl Acad Sci U S A
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  • BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1. Wu S et al., 2020 Jun, PLoS Genet
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  • An N-terminal Flag-tag impairs TPP1 regulation of telomerase function. Sandhu R et al., 2019 Apr 30, Biochem Biophys Res Commun
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  • Looping-out mechanism for resolution of replicative stress at telomeres. Zhang T et al., 2017 Aug, EMBO Rep
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  • Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nera B et al., 2015 Dec 7, Nat Commun
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  • XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma. Cheng J et al., 2015 Dec, Cancer Sci
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  • The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas. Tian XP et al., 2014 Oct 10, Cancer Lett
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  • Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase. Siddiqa A et al., 2012, J Oncol
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