TRF1 antibody [4E4]
GTX70304
ApplicationsImmunoFluorescence, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetTERF1
Overview
- SupplierGeneTex
- Product NameTRF1 antibody [4E4]
- Delivery Days Customer9
- Application Supplier NoteICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID4E4
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID7013
- Target nameTERF1
- Target descriptiontelomeric repeat binding factor 1
- Target synonymshTRF1-AS; NIMA-interacting protein 2; PIN2; telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat-binding factor 1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1; t-TRF1
- HostMouse
- IsotypeIgG1
- Protein IDP54274
- Protein NameTelomeric repeat-binding factor 1
- Scientific DescriptionThis gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability. Chen L et al., 2022 Nov 11, Nucleic Acids ResRead more
- cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence. Li X et al., 2022 Jan, Protein CellRead more
- The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment. Sandhu R et al., 2021 Jul 27, Proc Natl Acad Sci U S ARead more
- BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1. Wu S et al., 2020 Jun, PLoS GenetRead more
- An N-terminal Flag-tag impairs TPP1 regulation of telomerase function. Sandhu R et al., 2019 Apr 30, Biochem Biophys Res CommunRead more
- Looping-out mechanism for resolution of replicative stress at telomeres. Zhang T et al., 2017 Aug, EMBO RepRead more
- Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nera B et al., 2015 Dec 7, Nat CommunRead more
- XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma. Cheng J et al., 2015 Dec, Cancer SciRead more
- The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas. Tian XP et al., 2014 Oct 10, Cancer LettRead more
- Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase. Siddiqa A et al., 2012, J OncolRead more