TRPM4 antibody [3C4]

GeneTex

TRPM4 antibody [3C4] - Overexpression Validated

9

WB: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Monoclonal

3C4

1.2 mg/ml

Unconjugated

TRPM4

transient receptor potential cation channel subfamily M member 4

calcium-activated non-selective cation channel 1; EKVP6; hTRPM4; long transient receptor potential channel 4; LTrpC4; melastatin-4; PFHB1B; transient receptor potential cation channel subfamily M member 4; TRPM4B

Mouse

IgG1

Transient receptor potential cation channel subfamily M member 4

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203