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Tryptophanyl tRNA synthetase antibody

GTX110223
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetWARS1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Tryptophanyl tRNA synthetase antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7453
  • Target name
    WARS1
  • Target description
    tryptophanyl-tRNA synthetase 1
  • Target synonyms
    GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA, WARS, tryptophan--tRNA ligase, cytoplasmic, epididymis secretory sperm binding protein, hWRS, interferon-induced protein 53, trpRS, tryptophan tRNA ligase 1, cytoplasmic
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP23381
  • Protein Name
    Tryptophan--tRNA ligase, cytoplasmic
  • Scientific Description
    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Yamashita N, Morimoto Y, Fushimi A, et al. MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer. Mol Cancer Res. 2023,21(3):274-289. doi: 10.1158/1541-7786.MCR-22-0772
    Read this paper
  • Hagiwara M, Fushimi A, Bhattacharya A, et al. MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer. Oncoimmunology. 2022,11(1):2029298. doi: 10.1080/2162402X.2022.2029298
    Read this paper

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