UbcH5a/UBE2D1 (human) (rec.) (untagged)

South Bay Bio

UbcH5a/UBE2D1 (human) (rec.) (untagged)

10

Research Use Only

>95%

UBE2D1

ubiquitin conjugating enzyme E2 D1

E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, ubiquitin-conjugating enzyme E2 D1, (E3-independent) E2 ubiquitin-conjugating enzyme D1, E2 ubiquitin-conjugating enzyme D1, UBC4/5 homolog, stimulator of Fe transport, ubiquitin carrier protein D1, ubiquitin conjugating enzyme E2D 1, ubiquitin-conjugating enzyme E2(17)KB 1, ubiquitin-conjugating enzyme E2-17 kDa 1, ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast), ubiquitin-protein ligase D1

Ubiquitin-conjugating enzyme E2 D1

Protein. Human UBE2D1 (aa1-147)is untagged. Source: E. coli. Formulation: Liquid. In 50mM HEPES pH 7.5, 150mM sodium chloride, 10% glycerol (v/v), 2mM TCEP. Purity: >95% (SDS-PAGE). UBE2D1 (UbcH5a) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D1 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D1-Ub thioester. UBE2D1 is capable of associating with numerous known E3 ligases which target abnormal proteins for proteasomal degradation through polyubiquitination. UBE2D1 is also known to interact with Parkin and to be involved in PINK1 mediated mitophagy. - UBE2D1 (UbcH5a) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D1 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D1-Ub thioester. UBE2D1 is capable of associating with numerous known E3 ligases which target abnormal proteins for proteasomal degradation through polyubiquitination. UBE2D1 is also known to interact with Parkin and to be involved in PINK1 mediated mitophagy.

-80°C

41116100

Human