UbcH5c/UBE2D3 (human) (rec.) (untagged)

South Bay Bio

UbcH5c/UBE2D3 (human) (rec.) (untagged)

10

Research Use Only

>95%

UBE2D3

ubiquitin conjugating enzyme E2 D3

E2(17)KB3, UBC4/5, UBCH5C, ubiquitin-conjugating enzyme E2 D3, (E3-independent) E2 ubiquitin-conjugating enzyme D3, E2 ubiquitin-conjugating enzyme D3, ubiquitin carrier protein D3, ubiquitin conjugating enzyme E2D 3, ubiquitin-conjugating enzyme E2(17)KB 3, ubiquitin-conjugating enzyme E2-17 kDa 3, ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5), ubiquitin-protein ligase D3

Ubiquitin-conjugating enzyme E2 D3

Protein. Human UBE2D3 (aa1-147)is untagged. Source: E. coli. Formulation: Liquid. In 50mM HEPES pH 8, 200mM sodium chloride, 10% glycerol (v/v), 1mM TCEP. Purity: >95% (SDS-PAGE). UBE2D3 (UbcH5c) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D3 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D3-Ub thioester. UBE2D3 is capable of associating with numerous known E3 ligases including MDM2, which target proteins such as p53 for proteasomal degradation through polyubiquitination. - UBE2D3 [UbcH5c] is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D3 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D3-Ub thioester. UBE2D3 is capable of associating with numerous known E3 ligases including MDM2, which target proteins such as p53 for proteasomal degradation through polyubiquitination.

-80°C

41116100

Human