UBE2D2 [UbcH5b] (human) (rec.) (untagged)

South Bay Bio

UBE2D2 [UbcH5b] (human) (rec.) (untagged)

10

Research Use Only

>95%

UBE2D2

ubiquitin conjugating enzyme E2 D2

E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin-conjugating enzyme E2 D2, (E3-independent) E2 ubiquitin-conjugating enzyme D2, E2 ubiquitin-conjugating enzyme D2, p53-regulated ubiquitin-conjugating enzyme 1, ubiquitin carrier protein D2, ubiquitin conjugating enzyme E2D 2, ubiquitin-conjugating enzyme E2-17 kDa 2, ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5), ubiquitin-protein ligase D2

Ubiquitin-conjugating enzyme E2 D2

Protein. Human UBE2D2 (aa1-147)is untagged. Source: E. coli. Formulation: Liquid. In 50mM HEPES pH 7.5, 150mM sodium chloride, 10% glycerol (v/v), 2mM TCEP. Purity: >95% (SDS-PAGE). UBE2D2 (UbcH5b) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D2 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D2-Ub thioester. UBE2D2 is capable of associating with numerous known E3 ligases which target abnormal proteins for proteasomal degradation through polyubiquitination. UBE2D2 is also known to interact with Parkin and to be involved in PINK1 mediated mitophagy. - UBE2D2 (UbcH5b) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D2 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D2-Ub thioester. UBE2D2 is capable of associating with numerous known E3 ligases which target abnormal proteins for proteasomal degradation through polyubiquitination. UBE2D2 is also known to interact with Parkin and to be involved in PINK1 mediated mitophagy.

-80°C

41116100

Human