UEV1A antibody

GeneTex

UEV1A antibody

9

WB: 1 - 4 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

UBE2V1

ubiquitin conjugating enzyme E2 V1

CIR1; CROC1; CROC-1; DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V; ubiquitin-conjugating enzyme E2 variant 1; UEV1; UEV-1; UEV1A

Rabbit

IgG

Ubiquitin-conjugating enzyme E2 variant 1

Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).

-20°C or -80°C,2°C to 8°C

12352203