
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA100309(ULBP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200)
ULBP1 Antibody
CSB-PA100309
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetULBP1
Overview
- SupplierCusabio
- Product NameULBP1 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID80329
- Target nameULBP1
- Target descriptionUL16 binding protein 1
- Target synonymsN2DL-1, NKG2DL1, RAET1I, UL16-binding protein 1, NKG2D ligand 1, alcan-beta, retinoic acid early transcript 1I
- HostRabbit
- IsotypeIgG
- Protein IDQ9BZM6
- Protein NameUL16-binding protein 1
- Scientific DescriptionLigand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161




