UNC2025

MedChem Express

UNC2025 [1429881-91-3]

10

1429881-91-3

Research Use Only

99.83

C28H40N6O

476.66

UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC 50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl ( IC 50 = 122 nM; K i = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia [1] .

CN1CCN(CC2=CC=C(C3=CN([C@@H]4CC[C@@H](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1

-20°C,2°C to 8°C

12352200