Activation assay analysis of HUVECs pre-treated with 5.0 and 25 microg/ml GTX53462 VEGF Receptor 2 antibody [6B11] and then stimulated with rhVEGF (10ng/ml) for 30min. The phospho-VEGFR2 was detected by detected with IP-Western for P-Tyrosine.
Activation assay analysis of HUVECs pre-treated with 5.0 and 25 microg/ml GTX53462 VEGF Receptor 2 antibody [6B11] and then stimulated with rhVEGF (10ng/ml) for 30min. The phospho-VEGFR2 was detected by detected with IP-Western for P-Tyrosine.
VEGF Receptor 2 antibody [6B11]
GTX53462
ApplicationsWestern Blot, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityHuman
TargetKDR
Overview
- SupplierGeneTex
- Product NameVEGF Receptor 2 antibody [6B11] - Orthogonal Validated
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes hVEGFR-2 in western blot and it shows no cross-reactivity with hVEGFR-1.
- ApplicationsWestern Blot, Neutralisation/Blocking, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID6B11
- ConjugateUnconjugated
- Gene ID3791
- Target nameKDR
- Target descriptionkinase insert domain receptor
- Target synonymsCD309; fetal liver kinase-1; FLK1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; vascular endothelial growth factor receptor 2; VEGFR; VEGFR2
- HostMouse
- IsotypeIgG1
- Protein IDP35968
- Protein NameVascular endothelial growth factor receptor 2
- Scientific DescriptionVascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Blockade of insulin receptor substrate-1 inhibits biological behavior of choroidal endothelial cells. Qian YY et al., 2019, Int J OphthalmolRead more