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ProductsBack/Vinculin antibody [N3C1], Internal

Vinculin antibody [N3C1], Internal

Research Use Only
GTX109749
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat
TargetVCL
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Overview

  • Supplier
    GeneTex
  • Product Name
    Vinculin antibody [N3C1], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.11 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7414
  • Target name
    VCL
  • Target description
    vinculin
  • Target synonyms
    CMD1W; CMH15; epididymis luminal protein 114; epididymis secretory sperm binding protein; HEL114; metavinculin; meta-vinculin; MV; MVCL; vinculin; vinculin isoform meta-VCL
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP18206
  • Protein Name
    Vinculin
  • Scientific Description
    Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Porcine, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Lee YZ et al., 2022 Jul 21, Pharmaceutics
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  • Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch. Yang CW et al., 2022 Feb 17, Pharmaceuticals (Basel)
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  • Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy. Novak JS et al., 2021, J Neuromuscul Dis
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  • FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice. Cunningham S et al., 2021 Mar 1, Cancers (Basel)
    Read more
  • Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9: The Role of STAT3. Macchi C et al., 2020 Nov, Am J Pathol
    Read more
  • Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. Huang HY et al., 2020 Sep, J Cell Mol Med
    Read more
  • Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis. Yang CW et al., 2020 Oct, Biochem Pharmacol
    Read more
  • Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis. Chou CW et al., 2019 Dec 31, Sci Rep
    Read more
  • Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha. Lee YZ et al., 2020 Feb, Pharmacol Res
    Read more
  • Ferulic acid attenuates arsenic-induced cardiotoxicity in rats. Panneerselvam L et al., 2020 Mar, Biotechnol Appl Biochem
    Read more