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Vinculin antibody [N3C1], Internal

Name: Vinculin antibody [N3C1], Internal
SKU: GTX109749_G10
Availability: BackOrder

GTX109749

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

DownloadDatasheet

Product group Antibodies

TargetVCL

Overview

Supplier
GeneTex
Product Name
Vinculin antibody [N3C1], Internal
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.11 mg/ml
Conjugate
Unconjugated
Gene ID7414
Target name
VCL
Target description
vinculin
Target synonyms
CMD1W; CMH15; epididymis luminal protein 114; epididymis secretory sperm binding protein; HEL114; metavinculin; meta-vinculin; MV; MVCL; vinculin; vinculin isoform meta-VCL
Host
Rabbit
Isotype
IgG
Protein IDP18206
Protein Name
Vinculin
Scientific Description
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Lee YZ et al., 2022 Jul 21, Pharmaceutics
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Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch. Yang CW et al., 2022 Feb 17, Pharmaceuticals (Basel)
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Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy. Novak JS et al., 2021, J Neuromuscul Dis
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FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice. Cunningham S et al., 2021 Mar 1, Cancers (Basel)
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Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9: The Role of STAT3. Macchi C et al., 2020 Nov, Am J Pathol
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Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. Huang HY et al., 2020 Sep, J Cell Mol Med
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Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis. Yang CW et al., 2020 Oct, Biochem Pharmacol
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Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis. Chou CW et al., 2019 Dec 31, Sci Rep
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Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha. Lee YZ et al., 2020 Feb, Pharmacol Res
Read more
Ferulic acid attenuates arsenic-induced cardiotoxicity in rats. Panneerselvam L et al., 2020 Mar, Biotechnol Appl Biochem
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Vinculin antibody [N3C1], Internal

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Overview

References

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