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ProductsBack/Vitexin [3681-93-4]
Chemical Structure
Chemical Structure
Chemical Structure

Vitexin [3681-93-4]

Research Use Only
AG-CN2-0425
AdipoGen Life Sciences
CAS Number3681-93-4
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight432.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Vitexin
  • Delivery Days Customer
    10
  • CAS Number
    3681-93-4
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C21H20O10
  • Molecular Weight
    432.4
  • Scientific Description
    alpha-Glucosidase inhibitor [3, 8]. Antioxidant [1, 3]. HIF-1 alpha inhibitor [2]. Anti-metastatic [2, 13]. Apoptosis inducer [4, 9, 13]. Tumor suppressor [4, 9]. Adipogenesis inhibitor [5]. Inhibits SIRT6 in vitro [6]. Inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K [7]. Cardioprotective [10]. Anti-inflammatory [11]. Shows analgesic effect by targeting TRPV1 channel activity [11]. Neuroprotective. Inhibits NMDA receptors [12]. - Chemical. CAS: 3681-93-4. Formula: C21H20O10. MW: 432.4. Isolated from Crataegus pinnatifida. alpha-Glucosidase inhibitor. Antioxidant. HIF-1 alpha inhibitor. Anti-metastatic. Apoptosis inducer. Tumor suppressor. Adipogenesis inhibitor. Inhibits SIRT6 in vitro. Inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Cardioprotective. Anti-inflammatory. Shows analgesic effect by targeting TRPV1 channel activity. Neuroprotective. Inhibits NMDA receptors.
  • SMILES
    OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=C2OC(=CC(=O)C2=C(O)C=C1O)C1=CC=C(O)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • The isolation and antioxidative effects of vitexin from Acer palmatum: J.H. Kim, et al.; Arch. Pharm. Res. 28, 195 (2005)
  • Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells: H.J. Choi, et al.; Mol. Cells 22, 291 (2006)
  • Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity: M. Shibano, et al.; J. Nat. Med. 62, 349 (2008)
  • Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth: Y. Zhou, et al.; Clin. Cancer Res. 15, 5161 (2009)
  • Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells: J. Kim, et al.; Phytother. Res. 24, 1543 (2010)
  • Synthesis and characterization of SIRT6 protein coated magnetic beads: identification of a novel inhibitor of SIRT6 deacetylase from medicinal plant extracts: M. Yasuda, et al.; Anal. Chem. 83, 7400 (2011)
  • Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K: K.M. Helms, et al.; Nat. Prod. Commun. 6, 1411 (2011)
  • Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo alpha-glucosidase inhibition: C.Y. Choo, et al.; J. Ethnopharmacol. 142, 776 (2012)
  • Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway: C.Y. Lee, et al.; Oncol. Rep. 28, 1883 (2012)
  • Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways: C.C. Lu, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 386, 747 (2013)