ProductsBack/XRCC4 antibody

XRCC4 antibody

Name: XRCC4 antibody
SKU: GTX109632_G10
Availability: BackOrder

GTX109632

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetXRCC4

Overview

Supplier
GeneTex
Product Name
XRCC4 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.09 mg/ml
Conjugate
Unconjugated
Gene ID7518
Target name
XRCC4
Target description
X-ray repair cross complementing 4
Target synonyms
DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4
Host
Rabbit
Isotype
IgG
Protein IDQ13426
Protein Name
DNA repair protein XRCC4
Scientific Description
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease.
Read more
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition. Bakr A et al., 2021 Nov 18, Nucleic Acids Res
Read more
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Chakraborty A et al., 2016 Oct 5, Nat Commun
Read more
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. Chakraborty A et al., 2015 Oct 9, J Biol Chem
Read more
Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication. Truong LN et al., 2014 Oct 17, J Biol Chem
Read more
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. Sousa MM et al., 2013, PLoS One
Read more