XRCC4 antibody
GTX109632
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetXRCC4
Overview
- SupplierGeneTex
- Product NameXRCC4 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.09 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID7518
- Target nameXRCC4
- Target descriptionX-ray repair cross complementing 4
- Target synonymsDNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4
- HostRabbit
- IsotypeIgG
- Protein IDQ13426
- Protein NameDNA repair protein XRCC4
- Scientific DescriptionThe protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition. Bakr A et al., 2021 Nov 18, Nucleic Acids ResRead more
- Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Chakraborty A et al., 2016 Oct 5, Nat CommunRead more
- Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. Chakraborty A et al., 2015 Oct 9, J Biol ChemRead more
- Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication. Truong LN et al., 2014 Oct 17, J Biol ChemRead more
- An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. Sousa MM et al., 2013, PLoS OneRead more