XRCC4 Monoclonal Antibody

Reddot Biotech

XRCC4 Monoclonal Antibody

5

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

Clone:8K2

1 mg/ml

Unconjugated

XRCC4

X-ray repair cross complementing 4

DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4

Mouse

IgG

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Human

-20°C

12352203