YKL-5-124

AbMole BioScience

YKL-5-124

9

1957203-01-8

Chemical

Research Use Only

C28H33N7O3

515.61

YKL-5-124 is a potent, selective, irreversible COVALENT inhibitor of CDK7 and CDK7/Mat1/CycH IC50 53.5 nM and 9.7 nM, respectively. YKL-5-124 is more than 100 times more selective to CDK7 than CDK9 and CDK2 and is inactive to CDK12 and CDK13. YKL-5-124 induces intense cell cycle arrest and inhibits E2F-driven gene expression with little effect on RNA polymerase II phosphorylation status.

CN(C)CC(NC(=O)N1CC2=C([NH]N=C2NC(=O)C3=CC=C(NC(=O)C=C)C=C3)C1(C)C)C4=CC=CC=C4

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