Zorifertinib

MedChem Express

Zorifertinib [1626387-80-1]

9

1626387-80-1

Research Use Only

99.37

C22H23ClFN5O3

459.90

Zorifertinib (AZD3759) is a potent, orally active, central nervous system-penetrant, EGFR inhibitor. At K m ATP concentrations, the IC 50 s are 0.3, 0.2, and 0.2 nM for EGFR wt , EGFR L858R , and EGFR exon 19Del , respectively. Zorifertinib induces cancer cell apoptosis . Zorifertinib has antitumor activity, and can be used for NSCLC, HCC etc. research [1] .

ClC1=CC=CC(NC2=NC=NC3=CC(OC)=C(OC(N4[C@H](C)CN(C)CC4)=O)C=C23)=C1F

-20°C,2°C to 8°C

12352200