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ProductsBack/Zotatifin

Zotatifin

S8994

Estimated Purity...

Product group Chemicals

Overview

Supplier
Selleck Chemicals
Product Name
Zotatifin
Delivery Days Customer
9
Certification
Research Use Only
Estimated Purity
...
Scientific Description
Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.
UNSPSC
51202000

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