ABCG2 antibody [BXP-21]
GTX23380
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetABCG2
Product GTX23380 is not available
Product not available
There may be an alternative product available, please contact our technical support team.
Overview
- SupplierGeneTex
- Product NameABCG2 antibody [BXP-21]
- Delivery Days Customer9
- Antibody SpecificityReacts with an internal epitope of BCRP. Does not cross-react with the human MDR1, MRP1, MRP2 gene products.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDBXP-21
- ConjugateUnconjugated
- Gene ID9429
- Target nameABCG2
- Target descriptionATP binding cassette subfamily G member 2 (Junior blood group)
- Target synonymsABC transporter; ABC15; ABCP; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); BCRP; BCRP1; BMDP; breast cancer resistance protein; broad substrate specificity ATP-binding cassette transporter ABCG2; CD338; CDw338; EST157481; GOUT1; mitoxantrone resistance-associated protein; MRX; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; MXR; MXR1; MXR-1; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; UAQTL1; urate exporter
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionBreast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor. Cai CY et al., 2020 May, Biochem PharmacolRead more
- Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer. Zhang YK et al., 2019 Feb 1, Cancer LettRead more
- Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. Zhang GN et al., 2018 Jun 28, Cancer LettRead more
- Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib. Zhang GN et al., 2017 May, Pharmacol ResRead more
- Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters. Zhang YK et al., 2016 May 9, Sci RepRead more
- A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. Kim DG et al., 2016 May 2, J Clin InvestRead more
- ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer. Trumpi K et al., 2015, J CancerRead more
- Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography. Yamasaki T et al., 2011 Jul, Nucl Med BiolRead more
- Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancer. Yonemori K et al., 2010 Jan 15, CancerRead more