ABCG2 antibody [BXP-21]
GTX23380
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetABCG2
Overview
- SupplierGeneTex
- Product NameABCG2 antibody [BXP-21]
- Delivery Days Customer9
- Antibody SpecificityReacts with an internal epitope of BCRP. Does not cross-react with the human MDR1, MRP1, MRP2 gene products.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDBXP-21
- ConjugateUnconjugated
- Gene ID9429
- Target nameABCG2
- Target descriptionATP binding cassette subfamily G member 2 (Junior blood group)
- Target synonymsABC transporter; ABC15; ABCP; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); BCRP; BCRP1; BMDP; breast cancer resistance protein; broad substrate specificity ATP-binding cassette transporter ABCG2; CD338; CDw338; EST157481; GOUT1; mitoxantrone resistance-associated protein; MRX; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; MXR; MXR1; MXR-1; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; UAQTL1; urate exporter
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionBreast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor. Cai CY et al., 2020 May, Biochem PharmacolRead more
- Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer. Zhang YK et al., 2019 Feb 1, Cancer LettRead more
- Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. Zhang GN et al., 2018 Jun 28, Cancer LettRead more
- Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib. Zhang GN et al., 2017 May, Pharmacol ResRead more
- Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters. Zhang YK et al., 2016 May 9, Sci RepRead more
- A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. Kim DG et al., 2016 May 2, J Clin InvestRead more
- ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer. Trumpi K et al., 2015, J CancerRead more
- Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography. Yamasaki T et al., 2011 Jul, Nucl Med BiolRead more
- Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancer. Yonemori K et al., 2010 Jan 15, CancerRead more