Bio-Connect

ACVR2B Polyclonal Antibody

RD84766A
Reddot Biotech
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman
TargetACVR2B
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    ACVR2B Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoFluorescence
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID93
  • Target name
    ACVR2B
  • Target description
    activin A receptor type 2B
  • Target synonyms
    activin A receptor, type IIB; activin receptor type-2B; ACTRIIB; ActR-IIB; HTX4
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203