ACVR2B Polyclonal Antibody
RD84766A
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman
TargetACVR2B
Overview
- SupplierReddot Biotech
- Product NameACVR2B Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID93
- Target nameACVR2B
- Target descriptionactivin A receptor type 2B
- Target synonymsactivin A receptor, type IIB; activin receptor type-2B; ACTRIIB; ActR-IIB; HTX4
- HostRabbit
- IsotypeIgG
- Scientific DescriptionActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203