ADAMTS5 antibody
GTX100332
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetADAMTS5
Overview
- SupplierGeneTex
- Product NameADAMTS5 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID11096
- Target nameADAMTS5
- Target descriptionADAM metallopeptidase with thrombospondin type 1 motif 5
- Target synonymsa disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM-TS 11; ADAM-TS 5; ADAMTS11; ADAMTS-11; ADAM-TS5; ADAMTS-5; ADMP-2; aggrecanase-2
- HostRabbit
- IsotypeIgG
- Protein IDQ9UNA0
- Protein NameA disintegrin and metalloproteinase with thrombospondin motifs 5
- Scientific DescriptionThis gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Feasibility of administration of calcitonin gene-related peptide receptor antagonist on attenuation of pain and progression in osteoarthritis.Read more
- miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models.Read more
- Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis model.Read more
- Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model.Read more
- Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Park DR et al., 2020 Aug 28, Nat CommunRead more
- ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease. Wang Z et al., 2019, Dis MarkersRead more
- Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone. Kanemitsu M et al., 2020 Sep, J Orthop SciRead more
- Wwp2 maintains cartilage homeostasis through regulation of Adamts5. Mokuda S et al., 2019 Jun 3, Nat CommunRead more
- Connexin43 Mediated Delivery of ADAMTS5 Targeting siRNAs from Mesenchymal Stem Cells to Synovial Fibroblasts. Liu S et al., 2015, PLoS OneRead more