ADAMTS5 antibody
GTX100332
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetADAMTS5
Overview
- SupplierGeneTex
- Product NameADAMTS5 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID11096
- Target nameADAMTS5
- Target descriptionADAM metallopeptidase with thrombospondin type 1 motif 5
- Target synonymsADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 5, a disintegrin and metalloproteinase with thrombospondin motifs 11, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2), aggrecanase-2
- HostRabbit
- IsotypeIgG
- Protein IDQ9UNA0
- Protein NameA disintegrin and metalloproteinase with thrombospondin motifs 5
- Scientific DescriptionThis gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Nekomoto A, Nakasa T, Ikuta Y, et al. Feasibility of administration of calcitonin gene-related peptide receptor antagonist on attenuation of pain and progression in osteoarthritis. Sci Rep. 2023,13(1):15354. doi: 10.1038/s41598-023-42673-2Read this paper
- Fujiwara Y, Ding C, Sanada Y, et al. miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models. Front Cell Dev Biol. 2022,10:1043259. doi: 10.3389/fcell.2022.1043259Read this paper
- Hsueh YH, Buddhakosai W, Le PN, et al. Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis model. J Orthop Translat. 2023,38:141-155. doi: 10.1016/j.jot.2022.10.004Read this paper
- Sanada Y, Ikuta Y, Ding C, et al. Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model. Arthritis Res Ther. 2022,24(1):235. doi: 10.1186/s13075-022-02916-5Read this paper
- Park DR, Kim J, Kim GM, et al. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Nat Commun. 2020,11(1):4343. doi: 10.1038/s41467-020-18208-yRead this paper
- Wang Z, Ye D, Ye J, et al. ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease. Dis Markers. 2019,2019:6129748. doi: 10.1155/2019/6129748Read this paper
- Kanemitsu M, Nakasa T, Shirakawa Y, et al. Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone. J Orthop Sci. 2020,25(5):897-906. doi: 10.1016/j.jos.2019.11.010Read this paper
- Mokuda S, Nakamichi R, Matsuzaki T, et al. Wwp2 maintains cartilage homeostasis through regulation of Adamts5. Nat Commun. 2019,10(1):2429. doi: 10.1038/s41467-019-10177-1Read this paper
- Liu S, Niger C, Koh EY, et al. Connexin43 Mediated Delivery of ADAMTS5 Targeting siRNAs from Mesenchymal Stem Cells to Synovial Fibroblasts. PLoS One. 2015,10(6):e0129999. doi: 10.1371/journal.pone.0129999Read this paper
Datasheet
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