Bio-Connect

ADAMTS5 antibody

GTX100332
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetADAMTS5
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Overview

  • Supplier
    GeneTex
  • Product Name
    ADAMTS5 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID11096
  • Target name
    ADAMTS5
  • Target description
    ADAM metallopeptidase with thrombospondin type 1 motif 5
  • Target synonyms
    a disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM-TS 11; ADAM-TS 5; ADAMTS11; ADAMTS-11; ADAM-TS5; ADAMTS-5; ADMP-2; aggrecanase-2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UNA0
  • Protein Name
    A disintegrin and metalloproteinase with thrombospondin motifs 5
  • Scientific Description
    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Feasibility of administration of calcitonin gene-related peptide receptor antagonist on attenuation of pain and progression in osteoarthritis.
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  • miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models.
    Read more
  • Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis model.
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  • Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model.
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  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Park DR et al., 2020 Aug 28, Nat Commun
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  • ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease. Wang Z et al., 2019, Dis Markers
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  • Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone. Kanemitsu M et al., 2020 Sep, J Orthop Sci
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  • Wwp2 maintains cartilage homeostasis through regulation of Adamts5. Mokuda S et al., 2019 Jun 3, Nat Commun
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  • Connexin43 Mediated Delivery of ADAMTS5 Targeting siRNAs from Mesenchymal Stem Cells to Synovial Fibroblasts. Liu S et al., 2015, PLoS One
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