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ProductsBack/AKR1B1 antibody [N1C3]

AKR1B1 antibody [N1C3]

GTX113381
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetAKR1B1
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Overview

  • Supplier
    GeneTex
  • Product Name
    AKR1B1 antibody [N1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.06 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID231
  • Target name
    AKR1B1
  • Target description
    aldo-keto reductase family 1 member B
  • Target synonyms
    ADR, ALDR1, ALR2, AR, aldo-keto reductase family 1 member B1, Lii5-2 CTCL tumor antigen, aldehyde reductase 1, aldose reductase, low Km aldose reductase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP15121
  • Protein Name
    Aldo-keto reductase family 1 member B1
  • Scientific Description
    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wu TT, Chen YY, Ho CY, et al. 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus. Antioxidants (Basel). 2021,10(7). doi: 10.3390/antiox10071086
    Read this paper
  • García-Arroyo FE, Tapia E, Muñoz-Jiménez I, et al. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxid Med Cell Longev. 2020,2020:8850266. doi: 10.1155/2020/8850266
    Read this paper
  • Yoshino H, Yamada Y, Enokida H, et al. Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma. PLoS One. 2020,15(7):e0236119. doi: 10.1371/journal.pone.0236119
    Read this paper
  • Wu TT, Chen YY, Chang HY, et al. AKR1B1-Induced Epithelial-Mesenchymal Transition Mediated by RAGE-Oxidative Stress in Diabetic Cataract Lens. Antioxidants (Basel). 2020,9(4). doi: 10.3390/antiox9040273
    Read this paper
  • García-Arroyo FE, Muñoz-Jiménez I, Gonzaga G, et al. A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose. Int J Mol Sci. 2019,20(22). doi: 10.3390/ijms20225764
    Read this paper
  • Mey JT, Blackburn BK, Miranda ER, et al. Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2018,314(2):R181-R190. doi: 10.1152/ajpregu.00159.2017
    Read this paper
  • Steinhauser CB, Landers M, Myatt L, et al. Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway. Biol Reprod. 2016,95(5):108.
    Read this paper
  • García-Arroyo FE, Cristóbal M, Arellano-Buendía AS, et al. Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury. Am J Physiol Regul Integr Comp Physiol. 2016,311(1):R57-65. doi: 10.1152/ajpregu.00354.2015
    Read this paper
  • Uzozie A, Nanni P, Staiano T, et al. Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study. Mol Cell Proteomics. 2014,13(5):1198-218. doi: 10.1074/mcp.M113.035105
    Read this paper

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