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alpha Cardiac Muscle Actin antibody

Name: alpha Cardiac Muscle Actin antibody
SKU: GTX101876_G10
Availability: BackOrder

GTX101876

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetACTC1

Overview

Supplier
GeneTex
Product Name
alpha Cardiac Muscle Actin antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.39 mg/ml
Conjugate
Unconjugated
Gene ID70
Target name
ACTC1
Target description
actin alpha cardiac muscle 1
Target synonyms
ACTC, ASD5, CMD1R, CMH11, LVNC4, actin, alpha cardiac muscle 1
Host
Rabbit
Isotype
IgG
Protein IDP68032
Protein Name
Actin, alpha cardiac muscle 1
Scientific Description
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Hoshimaru T, Nonoguchi N, Kosaka T, et al. Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor. Brain Sci. 2023,13(10). doi: 10.3390/brainsci13101477
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Miksiunas R, Aldonyte R, Vailionyte A, et al. Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices. Int J Mol Sci. 2021,22(23). doi: 10.3390/ijms222312702
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Henry S, Szabó V, Sutus E, et al. RYBP is important for cardiac progenitor cell development and sarcomere formation. PLoS One. 2020,15(7):e0235922. doi: 10.1371/journal.pone.0235922
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Miksiunas R, Rucinskas K, Janusauskas V, et al. Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells. Int J Mol Sci. 2020,21(14). doi: 10.3390/ijms21144845
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Oldershaw R, Owens WA, Sutherland R, et al. Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential. Stem Cells Dev. 2019,28(9):593-607. doi: 10.1089/scd.2018.0170
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Wanibuchi M, Ohtaki S, Ookawa S, et al. Actin, alpha, cardiac muscle 1 (ACTC1) knockdown inhibits the migration of glioblastoma cells in vitro. J Neurol Sci. 2018,392:117-121. doi: 10.1016/j.jns.2018.07.013
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Unuma K, Aki T, Nagano S, et al. The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. Biochem Biophys Res Commun. 2018,495(2):1668-1674. doi: 10.1016/j.bbrc.2017.12.020
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Robertson SYT, Wen X, Yin K, et al. Multiple Calcium Export Exchangers and Pumps Are a Prominent Feature of Enamel Organ Cells. Front Physiol. 2017,8:336. doi: 10.3389/fphys.2017.00336
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alpha Cardiac Muscle Actin antibody

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