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alpha Synuclein antibody

Research Use Only
GTX112799
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSNCA
Price on request
Packing Size
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    GeneTex
  • Product Name
    alpha Synuclein antibody
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID6622
  • Target name
    SNCA
  • Target description
    synuclein alpha
  • Target synonyms
    alpha-synuclein; I+/--synuclein; NACP; non A-beta component of AD amyloid; PARK1; PARK4; PD1; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); truncated alpha synuclein
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinsons Disease? Yin S et al., 2022 Feb, Mol Neurobiol
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  • Interaction between coxsackievirus B3 infection and alpha-synuclein in models of Parkinsons disease. Park SJ et al., 2021 Oct, PLoS Pathog
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  • Clinical and functional characterization of a novel STUB1 frameshift mutation in autosomal dominant spinocerebellar ataxia type 48 (SCA48). Chen HY et al., 2021 Sep 26, J Biomed Sci
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  • Synthetic mRNA-based differentiation method enables early detection of Parkinsons phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells. Akiyama T et al., 2021 Apr, Stem Cells Transl Med
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  • Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells. Kwon Y et al., 2020 Oct 17, Cell Death Dis
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  • Transcriptomic analysis of alpha-synuclein knockdown after T3 spinal cord injury in rats. Zeng H et al., 2019 Nov 14, BMC Genomics
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  • Exosomes from patients with Parkinsons disease are pathological in mice. Han C et al., 2019 Sep, J Mol Med (Berl)
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  • MPTP-induced vulnerability of dopamine neurons in A53T alpha-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation. Lee S et al., 2017 Nov, Korean J Physiol Pharmacol
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  • Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinsons disease. Bastias-Candia S et al., 2015 May-Jun, Environ Toxicol
    Read more