Anti-CCL3 / MIP-1 alpha Antibody

HUABIO

Anti-CCL3 / MIP-1 alpha Antibody

7

Western Blot

IF-Cell,IHC-P,FC,ELISA

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CCL3

C-C motif chemokine ligand 3

G0S19-1, LD78, LD78ALPHA, MIP-1-alpha, MIP1A, SCI, SCYA3, C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, PAT 464.1, SIS-beta, macrophage inflammatory protein 1-alpha, small inducible cytokine A3 (homologous to mouse Mip-1a), tonsillar lymphocyte LD78 alpha protein

Rabbit

IgG

C-C motif chemokine 3

Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, MIP-2, MIP-3alpha, MIP-3beta, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1beta is more selective than MIP-1alpha, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1alpha is a more potent lymphocyte chemoattractant than MIP-1beta and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1alpha has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1beta and RANTES.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161