Anti-CD18 [YFC51.1]

Absolute Antibody

Anti-CD18 [YFC51.1]

9

This antibody binds human CD18 and recognizes amino acid residues between 122 and 344, more particularly amino acids from two regions 123-163 and 302-344 of the human CD18 molecule (PMID: 10779511). Binding of CD18 and CD11 results in the formation of Lym

The original rat IgG2b version of this antibody was successful in blocking CD18. The human IgG1 version of this antibody was able to block CD18 but unable to bind human Clq and did not mediate antibody-dependent cellular cytotoxicity (PMID: 7688398). This antibody was used as one of the antibodies to study the effect of anti-LFA-1 panel of abs on T cell adhesion to ICAM-1 and ICAM-3 using ELISA (PMID: 7518468).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

YFC51.1

ITGB2

integrin subunit beta 2

CD18; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; integrin beta chain, beta 2; integrin beta-2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1; MAC-1; MF17; MFI7; truncated integrin beta-2

Human

IgG1

Integrin beta-2

This chimeric human antibody was made using the variable domain sequences of the original Rat IgG2b format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203