Anti-CD23 [IDEC-152 (Lumiliximab, 6G5) ]

Absolute Antibody

Anti-CD23 [IDEC-152 (Lumiliximab, 6G5) ]

9

This antibody is specific for human CD23.

This antibody is also known as Gomiliximab. It binds CD23 or FCER2, a membrane protein and a low affinity receptor for IgE. It is also involved in IgE regulation and inflammation in allergic disorders, such as allergic rhinitis and allergic asthma. Phase I clinical trials in patients with allergic asthma revealed that IDEC-152 is safe and well-tolerated (PMID: 13679816). This antibody is also reported to have antitumor activity against chronic lymphocytic leukemia (CLL) in clinical trials (Woodworth et al., 2004; Byrd et al., 2004). Phase 1 study of Lumiliximab in patients with relapsed or refractory chronic lymphocytic leukemia reported that it was well tolerated and had clinical activity in patients. Flow cytometric analyses of blood samples were conducted to assess changes in lymphocyte subsets and to study both CD23 expression and binding of lumiliximab during the treatment (PMID: 17671129). This antibody also causes apoptosis in vitro and in vivo in CLL cells and drug-resistant lymphoma cells (Pathan et al., 2004; Zou et al., 2004). Lumiliximab was also found to inhibit allergen-induced responses in antigen-presenting cells and may be involved in modulating antigen-presenting cells and reducing T H 2-type immune responses (PMID: 16210051). This antibody was also used in the detection of human CD23 in the B cell-derived exosomes using immunoprecipitation (PMID: 20876574).

Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

IDEC-152 (Lumiliximab, 6G5)

FCER2

Fc fragment of IgE receptor II

BLAST-2; CD23; CD23 antigen; CD23A; CLEC4J; C-type lectin domain family 4, member J; Fc epsilon receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); FCE2; fc-epsilon-RII; IGEBF; immunoglobulin E-binding factor; immunoglobulin epsilon-chain; low affinity immunoglobulin epsilon Fc receptor; lymphocyte IgE receptor

Human

IgG1

Low affinity immunoglobulin epsilon Fc receptor

This chimeric human antibody was made using the variable domain sequences of the original IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203