anti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)
AG-27B-6002PF
ApplicationsFunctional Assay, Flow Cytometry, Western Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityCanine, Human
TargetCD40LG
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)
- Delivery Days Customer10
- Antibody SpecificityRecognizes and binds human CD40L with an IC50 of 0.845microg/ml. Cross-reacts with canine CD40L.
- ApplicationsFunctional Assay, Flow Cytometry, Western Blot, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDhu5c8
- Concentration1 mg/ml
- Estimated Purity>95%
- Gene ID959
- Target nameCD40LG
- Target descriptionCD40 ligand
- Target synonymsCD154; CD40 antigen ligand; CD40 ligand; CD40L; CD40-L; gp39; hCD40L; HIGM1; IGM; IMD3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5
- HostHuman
- IsotypeIgG1
- Scientific DescriptionCD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases. - Recombinant Antibody. Recognizes and binds human CD40L with an IC50 of 0.845microg/ml. Cross-reacts with canine CD40L. Species cross-reactivity: Dog, Human. Clone: hu5c8. Isotype: Human IgG1kappa. Applications: FACS, FUNC, FUNC (Blocking), WB. Host: . Liquid. In PBS. CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
- ReactivityCanine, Human
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203