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anti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)

Research Use Only
AG-27B-6002PF
AdipoGen Life Sciences
ApplicationsFunctional Assay, Flow Cytometry, Western Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityCanine, Human
TargetCD40LG
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes and binds human CD40L with an IC50 of 0.845microg/ml. Cross-reacts with canine CD40L.
  • Applications
    Functional Assay, Flow Cytometry, Western Blot, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    hu5c8
  • Concentration
    1 mg/ml
  • Estimated Purity
    >95%
  • Gene ID959
  • Target name
    CD40LG
  • Target description
    CD40 ligand
  • Target synonyms
    CD154; CD40 antigen ligand; CD40 ligand; CD40L; CD40-L; gp39; hCD40L; HIGM1; IGM; IMD3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5
  • Host
    Human
  • Isotype
    IgG1
  • Scientific Description
    CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases. - Recombinant Antibody. Recognizes and binds human CD40L with an IC50 of 0.845microg/ml. Cross-reacts with canine CD40L. Species cross-reactivity: Dog, Human. Clone: hu5c8. Isotype: Human IgG1kappa. Applications: FACS, FUNC, FUNC (Blocking), WB. Host: . Liquid. In PBS. CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
  • Reactivity
    Canine, Human
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203