Anti-Cytokeratin 7 [OV-TL 12/30]
AB01648-1.1-BT

ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry
Product group Antibodies
TargetKRT7
Overview
- SupplierAbsolute Antibody
- Product NameAnti-Cytokeratin 7 [OV-TL 12/30]
- Delivery Days Customer9
- Application Supplier NoteCytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometry. Cytokeratin 7 (CK7) labeling can help distinguish between lung, breast carcinomas, and urothelial carcinomas that typically stain positive, and colon and prostate carcinomas that typically lack CK7 expression (Jerome et al., 2004; Logani et al., 2003; Murray et al., 2004; Roy et al., 2011). CK7 is a common marker of primary lung adenocarcinomas (almost all cases) with a lower specificity since it is also observed in other primary lung carcinomas and non-pulmonary carcinomas (Jerome et al., 2004). Anti-cytokeratin 7 has also been useful in the differential diagnosis of ovarian neoplasms (McCluggage et al., 2005). Furthermore, this antibody is a marker for distinguishing between the conjunctival and corneal surface epithelia which may be used in the diagnosis of limbal stem cell deficiency (LSCD) (Jirsova et al., 2011; pmid: 21693612). Finally, OV-TL 12/30 has proven very effective and popular in immunohistochemistry; for instance, one group used it to label cytokeratin-7 in human term placental samples (Koenig et al., 2014; pmid: 24326460).
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDOV-TL 12/30
- Gene ID3855
- Target nameKRT7
- Target descriptionkeratin 7
- Target synonymsCK7; CK-7; cytokeratin 7; K2C7; K7; keratin 7, type II; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7; keratin, type II cytoskeletal 7; sarcolectin; SCL; type II mesothelial keratin K7; type-II keratin Kb7
- HostMouse
- IsotypeIgG1
- Protein IDP08729
- Protein NameKeratin, type II cytoskeletal 7
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203