Anti-desmoglein-2 [6D8]

Absolute Antibody

Anti-desmoglein-2 [6D8]

7

This antibody recognizes human desmoglein-2. This clone does not cross-react with Desmoglein 1 or Desmoglein 3. The epitope is within the extracellular domain (EC3/EC4) of Desmoglein 2/DSG2. Desmoglein-2 is part of a cadherin protein family and is involve

The antibody 6D8 has been used successfully to identify and analyse desmoglein-2 via various methods. For instance, it was utilized to label desmoglein 2 in melanoma tissue samples via immunohistochemistry to investiagete expression pattern of DSG2 in this cancer (Tan et al., 2016; pmid: 27340778). Furthermore, this antibody was also used to label DSG2 during flow cytometric analysis of cells (Tan et al., 2016; pmid: 27340778). The antibody 6D8 has also been applied in a Western blot detection of desmogleins in transfected A-431D cells (Wahl, 2002; pmid: 11991815). Finally, this antibody immunoprecipitated desmoglein-a from A-431 cell extracts prepared in 0.1% Empigen BB (Wahl, 2002; pmid: 11991815).

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

WB; FC; IF; IHC; IP

Research Use Only

Monoclonal

6D8

DSG2

desmoglein 2

cadherin family member 5; CDHF5; desmoglein-2; HDGC

Human

IgG1

Desmoglein-2

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunizing mice with a recombinant human full-length DSG2 protein.

-20°C,2°C to 8°C

12352203