Anti-DLL3 [SC16.13]

Absolute Antibody

Anti-DLL3 [SC16.13]

9

The binding characterization of this antibody to human DLL3 was done using ELISA. Binding affinity of mouse IgG antibody for human DLL3 is 0.3 nM. This antibody can bind human DLL3 expressed on surface of 293 cells via flow cytometry. This antibody can mediate killing of tumor cells expressing DLL3. This antibody was covalently conjugated to PBD cytotoxic agent and the resulting ADCs resulted in tumor growth suppression lasting as long as 20 days. Humanized version is also available and drug conjugations made using the humanized versions also resulted in tumor suppression (US9089615).

Functional Assay, Flow Cytometry, ELISA

Research Use Only

Monoclonal

SC16.13

DLL3

delta like canonical Notch ligand 3

SCDO1, delta-like protein 3, delta-like 3, delta3, drosophila Delta homolog 3

Rabbit

IgG

Delta-like protein 3

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203