Anti-IL-17A [MM17F3]

Absolute Antibody

Anti-IL-17A [MM17F3]

7

This antibody is highly specific for murine IL-17A; in ELISA analysis, no cross-reactivity with IL-17B, IL-17C, IL-17D, IL-17E or IL-17F was observed.

The specificity of this antibody has been confirmed in ELISA analysis (Uyttenhove et al, 2006). This antibody inhibits IL-17A-induced IL-6 production by a Cl1D fibroblastic cell line in vitro (Uyttenhove et al, 2006). This antibody has been shown to prevent experimental autoimmune encephalomyelitis (EAE) disease development in vivo (Uyttenhove et al, 2006), as well as protecting C57Bl/6 mice from myelin oligdendrocyte glycoprotein (MOG)-induced EAE (Uyttenhove et al, 2007). Additionally, administration of this antibody inhibits collagen-induced arthritis (CIA) in IFN-gamma receptor knockout mice (Kelchtermans et al, 2009).

ELISA, Neutralisation/Blocking

ELISA; blocking; therapeutic

Research Use Only

Monoclonal

MM17F3

Il17a

interleukin 17A

Ctl; Ctla; Ctla8; Ctla-8; cytotoxic T-lymphocyte-associated antigen 8; Il; IL-; Il17; IL-17; IL-17A; interleukin-17A

Mouse

IgG2a

Interleukin-17A

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Mouse

Mouse

This antibody was raised by immunising C57Bl/6 mice with IL-17A cross-linked to ovalbumin to generate a highly immunogenic complex.

-20°C,2°C to 8°C

12352203