Anti-MET [7A2]

Absolute Antibody

Anti-MET [7A2]

9

The antibody specifically binds to amino acid residues 568-741 of human MET.

The scFv fragment showed inhibition of HGF/SF induced migration of SKOV cells. In particular, the scFv fragment had an IC50 of 2.3 nM in the SKOV migration assay. The binding affinity of the scFv fragment to MET928 was measured by surface plasmon resonance (Kd= 3.6 nM). In a competition ELISA, binding of 2.5 nM of the Fab version of the antibody to a MET928-coated surface was inhibited by 15 microM and 5 microM NK1 (US20150147274A1).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

7A2

MET

MET proto-oncogene, receptor tyrosine kinase

AUTS9; c-Met; DFNB97; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; proto-oncogene c-Met; RCCP2; scatter factor receptor; SF receptor; tyrosine-protein kinase Met

Rabbit

IgG

Hepatocyte growth factor receptor

Human

-20°C,2°C to 8°C

12352203