Anti-NKp46 [NKP46-4]

Absolute Antibody

Anti-NKp46 [NKP46-4]

7

The antibody is specific for human NKp46. The antibody cross-reacts with cynomolgus monkey and rhesus macaque NK46 but does not cross-react with mouse NKp46. NKp46 is a receptor expressed by NK cells.

The binding specificity of this antibody towards human, cynomolgus monkey and rhesus monkey NKp-46 was determined using ELISA and flow cytometry. The binding of this antibody to NKp-46 expressed on the surface of CHOK1 and NK cells was confirmed using flow cytometry. The original IgG antibody bound ectodomain of human NKp-46 with a binding affinity of Kd= 1.1 nM. This binding of this antibody to NK cells resulted in an increase in the interferon gamma release (CN113637074).

Flow Cytometry, ELISA

ELISA; FC

Research Use Only

Monoclonal

NKP46-4

NCR1

natural cytotoxicity triggering receptor 1

CD335; LY94; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); natural cytotoxicity triggering receptor 1; natural killer cell p46-related protein; NK cell-activating receptor; NKP46; NK-p46

Rabbit

IgG

Natural cytotoxicity triggering receptor 1

This full-length chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.

Human, Monkey, Primate

Human, cynomolgus monkey, rhesus macaque

The original antibody was isolated using phage display technology after three rounds of panning against human NKp-46.

-20°C,2°C to 8°C

12352203