Anti-PAI-1 [8H9D4]

Absolute Antibody

Anti-PAI-1 [8H9D4]

7

This antibody is reported to have strong inhibitory effect towards PAI-1 activity. The cross reactivity of this antibody towards other PAI-1 than human was done using ELISA (PMID: 9048903). This antibody shifts the reaction to the substrate pathway without decreasing the rate-limiting constant for reactive center loop insertion by tPA (PMID: 12223472). This antibody interferes with the final locking step in the serpin/proteinase interaction, thereby explaining its substrate inducing properties (PMID: 12871373).

ELISA, Neutralisation/Blocking

Inhibit; neutralize; ELISA

Research Use Only

Monoclonal

8H9D4

SERPINE1

serpin family E member 1

PAI, PAI-1, PAI1, PLANH1, plasminogen activator inhibitor 1, endothelial plasminogen activator inhibitor, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, serpin E1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Mouse

IgG1

Plasminogen activator inhibitor 1

Human, Porcine

Human, pig

The original antibody was generated using PAI-1 complex as an immunogen.

-20°C,2°C to 8°C

41116161