Anti-Tau [PC1C6]

Absolute Antibody

Anti-Tau [PC1C6]

9

This antibody was generated against purified denatured bovine microtubule associated proteins (MAPs) and recognizes human, rat, and bovine Tau1. Tau protein is a highly soluble microtubule-associated protein. In humans, these proteins are mostly found in

In the original study, this antibody was used in immunoblot assays and competitive ELISA to show that tau was more abundant in bovine white matter extracts and microtubules than in extracts and microtubules from an enriched gray matter region of the brain (Binder et al., 1985). Example of functional studies in which this antibody could be utilised include those conducted by Kosik et al. (PNAS 1986) to confirm that tau is a major antigenic component of paired helical filaments in Alzheimer disease, by Bramblett et al. (Neuron 1993) to demonstrate that abnormal tau phosphorylation at Ser396 in Alzheimers disease recapitulates development and contributes to reduced microtubule binding, by Stamer et al. (J Cell Biol. 2002) to suggests a linkage between tau and amyloid precursor protein (APP) trafficking, and by Strang et al. (JBC 2018) to provide novel insights in the molecular mechanisms of tau aggregation.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

PC1C6

MAPT

microtubule associated protein tau

DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40

Mouse

IgG2a

Microtubule-associated protein tau

Bovine, Human, Rat

-20°C,2°C to 8°C

12352203