APBB1 Antibody

Cusabio

APBB1 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

APBB1

amyloid beta precursor protein binding family B member 1

FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1, adaptor protein FE65a2, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), stat-like protein

Rabbit

IgG

Amyloid beta precursor protein binding family B member 1

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Tyr-142 (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Human

-20°C or -80°C

41116161