FE65 antibody

GeneTex

FE65 antibody

7

WB: 1:50 - 1:200. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Research Use Only

Polyclonal

Unconjugated

Liquid

APBB1

amyloid beta precursor protein binding family B member 1

adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid-beta A4 precursor protein-binding family B member 1; FE65; MGC:9072; RIR; stat-like protein

Rabbit

IgG

Amyloid-beta A4 precursor protein-binding family B member 1

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

-20°C or -80°C,2°C to 8°C

12352203