APC Anti-Mouse Foxp3 Antibody

Reddot Biotech

APC Anti-Mouse Foxp3 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

3G3

APC (Allophycocyanin)

Foxp3

forkhead box P3

forkhead box protein P3; JM2; scu; scurfin; scurfy; sf

Mouse

IgG1

FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25-?cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 Oe2) lacking exon 2.

Mouse

2°C to 8°C

12352203