APEX2 antibody, Internal

GeneTex

APEX2 antibody, Internal

9

WB: 1:1000. ICC/IF: 1:25. IHC-P: 1:10-1:50. FACS: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Liquid

APEX2

apurinic/apyrimidinic endodeoxyribonuclease 2

AP endonuclease 2; AP endonuclease XTH2; APE2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEXL2; apurinic/apyrimidinic endonuclease-like 2; DNA-(apurinic or apyrimidinic site) endonuclease 2; DNA-(apurinic or apyrimidinic site) lyase 2; XTH2; ZGRF2; zinc finger, GRF-type containing 2

DNA-(apurinic or apyrimidinic site) lyase 2

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

-20°C or -80°C,2°C to 8°C

12352203