ATF4 Antibody, Biotin conjugated

Cusabio

ATF4 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

ATF4

activating transcription factor 4

cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB2; CREB-2; cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; TAXREB67; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; TXREB

Rabbit

IgG

Cyclic AMP-dependent transcription factor ATF-4

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5\-GTGACGT[AC][AG]-3\), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).

Human

-20°C or -80°C

12352203