ATM antibody [2C1] (supernatant)

GeneTex

ATM antibody [2C1] (supernatant)

9

Recommended Starting Dilutions:For WB: Use at 1:100. For IP: Use at an assay dependent dilution. For IHC: Use at 1:50. Analysis was performed of the cerebral cortex of E14.5 wild-type (+/+) and scid mice - (MC Vemuri, 2001) For immunofluorescence please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. For ICC/IF: Use at 1:500. Optimal dilutions/concentrations should be determined by the researcher.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2C1

Unconjugated

ATM

ATM serine/threonine kinase

AT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1

Mouse

IgG1

Serine-protein kinase ATM

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

Human, Monkey, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203