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ATM antibody [2C1]

GTX70103
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetATM
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATM antibody [2C1] - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    Recommended Starting Dilutions:For WB: Use at a dilution of 1:500-1:3000. Predicted 350 kDa. For IHC-P: Use at 5 microg/mL. Antigen retrieval in Citrate buffer is recommended.For IP: Use at a concentration of 1-10 microg/ml. For ICC/IF: Please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. For FACS:Use at an dependent assay. Optimal dilutions/concentrations should be determined by the researcher.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2C1
  • Concentration
    0.99 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID472
  • Target name
    ATM
  • Target description
    ATM serine/threonine kinase
  • Target synonyms
    AT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ13315
  • Protein Name
    Serine-protein kinase ATM
  • Scientific Description
    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
  • Reactivity
    Human, Monkey, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
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  • Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.
    Read more
  • APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus.
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  • RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11.
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  • Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation.
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  • Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis. Agborbesong E et al., 2023 Jan 27, Hum Mol Genet
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  • New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53-P21 pathway. Li J et al., 2019 Nov 27, RSC Adv
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  • Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR. Wang F et al., 2022 Mar, Acta Pharm Sin B
    Read more
  • Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines. Yang SC et al., 2022 Jan 31, Int J Mol Sci
    Read more
  • 53BP1 regulates heterochromatin through liquid phase separation. Zhang L et al., 2022 Jan 18, Nat Commun
    Read more