ATM antibody [3E8]
GTX70105
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetATM
Overview
- SupplierGeneTex
- Product NameATM antibody [3E8]
- Delivery Days Customer9
- Application Supplier NoteWB: 1-2 microg/ml. IP: 2-10 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID472
- Target nameATM
- Target descriptionATM serine/threonine kinase
- Target synonymsAT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
- HostMouse
- IsotypeIgG1
- Protein IDQ13315
- Protein NameSerine-protein kinase ATM
- Scientific DescriptionThe protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- ReactivityHuman, Monkey, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Fini L et al., 2008 Jan, CarcinogenesisRead more
- Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Bai L et al., 2006 Sep, GastroenterologyRead more
- Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Shiotani B et al., 2006 Feb, Mol Cancer ResRead more
- Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Post S et al., 2001 Nov 6, Proc Natl Acad Sci U S ARead more
- ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. Chen MJ et al., 2001 May 11, J Biol ChemRead more