ATM antibody [5C2]
GTX70107
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
TargetATM
Overview
- SupplierGeneTex
- Product NameATM antibody [5C2]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5C2
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID472
- Target nameATM
- Target descriptionATM serine/threonine kinase
- Target synonymsAT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, serine-protein kinase ATM, A-T mutated, AT mutated, TEL1, telomere maintenance 1, homolog, ataxia telangiectasia mutated, serine/threonine kinase ATM
- HostMouse
- IsotypeIgG1
- Protein IDQ13315
- Protein NameSerine-protein kinase ATM
- Scientific DescriptionThe protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Xin D, Gai X, Ma Y, et al. Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response. Adv Sci (Weinh). 2023,10(28):e2206931. doi: 10.1002/advs.202206931Read this paper
- Yeo AJ, Subramanian GN, Chong KL, et al. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021,54:101354. doi: 10.1016/j.molmet.2021.101354Read this paper
- Chen X, Chen F, Ren Y, et al. IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2. J Cancer Res Clin Oncol. 2019,145(6):1471-1484. doi: 10.1007/s00432-019-02917-zRead this paper
- Yeo AJ, Fantino E, Czovek D, et al. Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress. Am J Respir Crit Care Med. 2017,196(3):391-393. doi: 10.1164/rccm.201611-2210LERead this paper
- Du F, Zhang M, Li X, et al. Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun. 2014,452(4):1034-9. doi: 10.1016/j.bbrc.2014.09.038Read this paper
- Javvadi P, Makino H, Das AK, et al. Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res. 2012,10(10):1359-68. doi: 10.1158/1541-7786.MCR-12-0482-TRead this paper
- Vogel R, Seyffert M, Strasser R, et al. Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol. 2012,86(1):143-55. doi: 10.1128/JVI.05694-11Read this paper
- Rankin AM, Sarkar S, Faller DV. Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. J Cell Physiol. 2012,227(6):2586-94. doi: 10.1002/jcp.22997Read this paper
- Gapud EJ, Dorsett Y, Yin B, et al. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011,108(5):2022-7. doi: 10.1073/pnas.1013295108Read this paper
- Cam H, Easton JB, High A, et al. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell. 2010,40(4):509-20. doi: 10.1016/j.molcel.2010.10.030Read this paper
Datasheet
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