ATM antibody [5C2]
GTX70107
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetATM
Overview
- SupplierGeneTex
- Product NameATM antibody [5C2] - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5C2
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID472
- Target nameATM
- Target descriptionATM serine/threonine kinase
- Target synonymsAT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
- HostMouse
- IsotypeIgG1
- Protein IDQ13315
- Protein NameSerine-protein kinase ATM
- Scientific DescriptionThe protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- ReactivityHuman, Monkey, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response.Read more
- An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Yeo AJ et al., 2021 Dec, Mol MetabRead more
- IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2. Chen X et al., 2019 Jun, J Cancer Res Clin OncolRead more
- Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress. Yeo AJ et al., 2017 Aug 1, Am J Respir Crit Care MedRead more
- Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Du F et al., 2014 Oct 3, Biochem Biophys Res CommunRead more
- Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Javvadi P et al., 2012 Oct, Mol Cancer ResRead more
- Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. Vogel R et al., 2012 Jan, J VirolRead more
- Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. Rankin AM et al., 2012 Jun, J Cell PhysiolRead more
- Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Gapud EJ et al., 2011 Feb 1, Proc Natl Acad Sci U S ARead more
- mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1alpha. Cam H et al., 2010 Nov 24, Mol CellRead more