ATM (phospho Ser1981) antibody
GTX132146
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetATM
Overview
- SupplierGeneTex
- Product NameATM (phospho Ser1981) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID472
- Target nameATM
- Target descriptionATM serine/threonine kinase
- Target synonymsAT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
- HostRabbit
- IsotypeIgG
- Protein IDQ13315
- Protein NameSerine-protein kinase ATM
- Scientific DescriptionThe protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Targeted photodynamic therapy of glioblastoma mediated by platelets with photo-controlled release property. Xu HZ et al., 2022 Nov, BiomaterialsRead more
- CTLA-4 Facilitates DNA Damage-Induced Apoptosis by Interacting With PP2A. Yan Q et al., 2022, Front Cell Dev BiolRead more
- Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin. Yuan SJ et al., 2021 Sep 5, Int J PharmRead more
- Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability. Chao T et al., 2021 Nov, AutophagyRead more
- Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway. Shen M et al., 2019 Apr 8, J Exp Clin Cancer ResRead more
- Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cells. Anuja K et al., 2019 Jun, Int J Radiat BiolRead more
- Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells. Benedict B et al., 2018 Oct 16, ElifeRead more
- Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen. Kozlov SV et al., 2016 Mar, Mol Cell ProteomicsRead more
- A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function. Menezes DL et al., 2015 Jan, Mol Cancer ResRead more
- N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo. Liu LY et al., 2013 Nov 18, Chem Res ToxicolRead more