
Western blot All lanes: ATXN3 antibody at 2microg/ml Lane 1: 293T whole cell lysate Lane 2: Mouse brain tissue Lane 3: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 42, 36, 40, 21 kDa Observed band size: 42 kDa
ATXN3 Antibody
CSB-PA002443LA01HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetATXN3
Overview
- SupplierCusabio
- Product NameATXN3 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4287
- Target nameATXN3
- Target descriptionataxin 3
- Target synonymsAT3; ataxin-3; ATX3; JOS; josephin; Machado-Joseph disease protein 1; MJD; MJD1; olivopontocerebellar ataxia 3; SCA3; spinocerebellar ataxia type 3 protein
- HostRabbit
- IsotypeIgG
- Protein IDP54252
- Protein NameAtaxin-3
- Scientific DescriptionDeubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C
- UNSPSC41116161





