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BGG463 [890129-26-7]

Research Use Only
SYN-1226
SYNkinase
CAS Number890129-26-7
Product group Chemicals
Estimated Purity>95%
Molecular Weight578.6
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Overview

  • Supplier
    SYNkinase
  • Product Name
    BGG463 [890129-26-7]
  • Delivery Days Customer
    10
  • CAS Number
    890129-26-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C30H29F3N6O3
  • Molecular Weight
    578.6
  • Scientific Description
    BGG463 (NVP-BGG463) was generated by a rational hybrid design approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive DFG-out conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 microM, 0.09 microM and 0.590 microM, respectively. - Chemical. CAS: 890129-26-7. Formula: C30H29F3N6O3. MW: 578.6. BGG463 (NVP-BGG463) was generated by a rational hybrid design approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive DFG-out conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 microM, 0.09 microM and 0.590 microM, respectively.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000