PF-4618433

SYNkinase

PF-4618433 [1166393-85-6]

10

1166393-85-6

Research Use Only

>95%

C24H27N7O2

445.5

Chemical. CAS: 1166393-85-6. Formula: C24H27N7O2. MW: 445.5. Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization. - Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.

-20°C,2°C to 8°C

51202000