
Chemical Structure
PF-4618433 [1166393-85-6]

SYN-1163
CAS Number1166393-85-6
Product group Chemicals
Estimated Purity>95%
Molecular Weight445.5
Overview
- SupplierSYNkinase
- Product NamePF-4618433 [1166393-85-6]
- Delivery Days Customer10
- CAS Number1166393-85-6
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC24H27N7O2
- Molecular Weight445.5
- Scientific DescriptionChemical. CAS: 1166393-85-6. Formula: C24H27N7O2. MW: 445.5. Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization. - Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.
- Storage Instruction2°C to 8°C
- UNSPSC51202000