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Chemical Structure
Chemical Structure
Chemical Structure

Bisindolylmaleimide I (free base) [GF-109203X; Goe 6850] [133052-90-1]

Research Use Only
AG-CR1-0009
AdipoGen Life Sciences
CAS Number133052-90-1
Product group Chemicals
Estimated Purity>97%
Molecular Weight412.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bisindolylmaleimide I (free base) [GF-109203X; Goe 6850]
  • Delivery Days Customer
    10
  • CAS Number
    133052-90-1
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C25H24N4O2
  • Molecular Weight
    412.5
  • Scientific Description
    Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM) [1]. Competetive inhibitor for the ATP-binding site of PKC [1]. Anti-inflammatory [2]. Binds to P-glycoprotein [3]. Telomerase activity inhibitor [4]. Potent glycogen synthase kinase-3 (GSK-3) inhibitor [5]. Necrosis inhibitor [6]. Blocks hERG potassium channels [7-9]. Promotes osteoblastogenesis in human mesenchymal stem cells [10]. - Chemical. CAS: 133052-90-1. Formula: C25H24N4O2. MW: 412.5. Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.
  • SMILES
    CN(C)CCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000